Search results for "mucosal secretion"

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Glucagon-like peptide-2 modulates neurally evoked mucosal chloride secretion in guinea pig small intestine in vitro

2009

Glucagon-like peptide-2 (GLP-2) is an important neuroendocrine peptide in intestinal physiology. It influences digestion, absorption, epithelial growth, motility, and blood flow. We studied involvement of GLP-2 in intestinal mucosal secretory behavior. Submucosal-mucosal preparations from guinea pig ileum were mounted in Ussing chambers for measurement of short-circuit current ( Isc) as a surrogate for chloride secretion. GLP-2 action on neuronal release of acetylcholine was determined with ELISA. Enteric neuronal expression of the GLP-2 receptor (GLP-2R) was studied with immunohistochemical methods. Application of GLP-2 (0.1–100 nM) to the serosal or mucosal side of the preparations evoke…

MaleTime FactorsPhysiologyVasoactive intestinal peptideHormones and SignalingFluorescent Antibody TechniqueSettore BIO/09 - FisiologiaEnteric Nervous SystemMembrane PotentialsIntestinal mucosaGlucagon-Like Peptide 2Receptors GlucagonNeuropeptide YIntestinal MucosaNeurotransmitter Agentsdigestive oral and skin physiologyGastroenterologygastrointestinal hormoneGlucagon-like peptide-2ImmunohistochemistrySomatostatinmedicine.anatomical_structureenteric nervous system; gastrointestinal hormones; intestine; mucosal secretionGlucagon-Like Peptide-2 ReceptorSomatostatinhormones hormone substitutes and hormone antagonistsVasoactive Intestinal Peptideendocrine systemmedicine.medical_specialtyGuinea PigsMotilityEnzyme-Linked Immunosorbent AssayIleumIn Vitro TechniquesBiologyCholine O-AcetyltransferaseChloridesIleumPhysiology (medical)Internal medicinemedicineAnimalsintestineIntestinal SecretionsHepatologymucosal secretionAcetylcholineElectric StimulationSmall intestineEndocrinologyGlucagon-Like Peptide-2 Receptor
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